Interrelationship between Changes in the Amyloid β 42/40 Ratio and Presenilin 1 Conformation

• Ngā kaituhi matua: Katarzyna Marta Zoltowska (Author), Masato Maesako (Author), Oksana Berezovska (Author)
• Hōputu: Pukapuka
• I whakaputaina: BMC, 2016-07-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Abstract The ratio of the longer (Aβ42/Aβ43) to shorter (Aβ40) species is a critical factor determining amyloid fibril formation, neurotoxicity and progression of the amyloid pathology in Alzheimer's disease. The relative levels of the different Aβ species are affected by activity and conformat...