Trichinella spiralis paramyosin binds to C8 and C9 and protects the tissue-dwelling nematode from being attacked by host complement.

• Main Authors: Zhifei Zhang (Author), Jing Yang (Author), Junfei Wei (Author), Yaping Yang (Author), Xiaoqin Chen (Author), Xi Zhao (Author), Yuan Gu (Author), Shijuan Cui (Author), Xinping Zhu (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Paramyosin is a thick myofibrillar protein found exclusively in invertebrates. Evidence suggested that paramyosin from helminths serves not only as a structural protein but also as an immunomodulatory agent. We previously reported that recombinant Trichinella spiralis paramyosin (Ts-Pmy)...