Drug discovery of sclerostin inhibitors

• Main Authors: Sifan Yu (Author), Dijie Li (Author), Ning Zhang (Author), Shuaijian Ni (Author), Meiheng Sun (Author), Luyao Wang (Author), Huan Xiao (Author), Dingdong Liu (Author), Jin Liu (Author), Yuanyuan Yu (Author), Zongkang Zhang (Author), Samuel Tin Yui Yeung (Author), Shu Zhang (Author), Aiping Lu (Author), Zhenlin Zhang (Author), Baoting Zhang (Author), Ge Zhang (Author)
• Format: Book
• Published: Elsevier, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-related diseases, making it a promising therapeutic...