Dysregulated systemic metabolism in a Down syndrome mouse model

• Main Authors: Dylan C. Sarver (Author), Cheng Xu (Author), Leandro M. Velez (Author), Susan Aja (Author), Andrew E. Jaffe (Author), Marcus M. Seldin (Author), Roger H. Reeves (Author), G. William Wong (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Trisomy 21 is one of the most complex genetic perturbations compatible with postnatal survival. Dosage imbalance arising from the triplication of genes on human chromosome 21 (Hsa21) affects multiple organ systems. Much of Down syndrome (DS) research, however, has focused on addressing ho...