Whipple Disease Presenting as Isolated Transverse Myelitis with Permanent Neurological Damage in a Patient with Systemic Lupus Erythematosus: A Case Report of a Difficult Diagnosis with a Literature Review

We describe an atypical case of Whipple disease exclusively involving the spinal cord in an adolescent receiving immunosuppressive therapy for systemic lupus erythematosus. The diagnosis was particularly difficult since lupus and Whipple disease can present similar clinical features and the patient&...

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Main Authors: Carolina Saffioti (Author), Marta Nebiolo (Author), Roberta Caorsi (Author), Alessio Mesini (Author), Mariasavina Severino (Author), Giacomo Brisca (Author), Elio Castagnola (Author), Marco Gattorno (Author)
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Published: MDPI AG, 2024-03-01T00:00:00Z.
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001 doaj_c0e6f99e4c5e47288a8d6dae7aaa0e63
042 |a dc 
100 1 0 |a Carolina Saffioti  |e author 
700 1 0 |a Marta Nebiolo  |e author 
700 1 0 |a Roberta Caorsi  |e author 
700 1 0 |a Alessio Mesini  |e author 
700 1 0 |a Mariasavina Severino  |e author 
700 1 0 |a Giacomo Brisca  |e author 
700 1 0 |a Elio Castagnola  |e author 
700 1 0 |a Marco Gattorno  |e author 
245 0 0 |a Whipple Disease Presenting as Isolated Transverse Myelitis with Permanent Neurological Damage in a Patient with Systemic Lupus Erythematosus: A Case Report of a Difficult Diagnosis with a Literature Review 
260 |b MDPI AG,   |c 2024-03-01T00:00:00Z. 
500 |a 10.3390/idr16020022 
500 |a 2036-7449 
520 |a We describe an atypical case of Whipple disease exclusively involving the spinal cord in an adolescent receiving immunosuppressive therapy for systemic lupus erythematosus. The diagnosis was particularly difficult since lupus and Whipple disease can present similar clinical features and the patient's prolonged contact with sewage was initially not mentioned. A literature review of the clinical, imaging, diagnostic, and therapeutic challenges of Whipple disease is also performed. 
546 |a EN 
690 |a <i>Tropheryma whipplei</i> 
690 |a Whipple disease 
690 |a systemic lupus erythematosus 
690 |a immunosuppressive therapy 
690 |a neuroimaging 
690 |a Other systems of medicine 
690 |a RZ201-999 
655 7 |a article  |2 local 
786 0 |n Infectious Disease Reports, Vol 16, Iss 2, Pp 269-280 (2024) 
787 0 |n https://www.mdpi.com/2036-7449/16/2/22 
787 0 |n https://doaj.org/toc/2036-7449 
856 4 1 |u https://doaj.org/article/c0e6f99e4c5e47288a8d6dae7aaa0e63  |z Connect to this object online.