Bepridil Facilitates Early Termination of Spiral-Wave Reentry in Two-Dimensional Cardiac Muscle Through an Increase of Intercellular Electrical Coupling

• Main Authors: Hiroki Takanari (Author), Haruo Honjo (Author), Yoshio Takemoto (Author), Tomoyuki Suzuki (Author), Sara Kato (Author), Masahide Harada (Author), Yusuke Okuno (Author), Takashi Ashihara (Author), Tobias Opthof (Author), Ichiro Sakuma (Author), Kaichiro Kamiya (Author), Itsuo Kodama (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bepridil is effective for conversion of atrial fibrillation to sinus rhythm and in the treatment of drug-refractory ventricular tachyarrhythmias. We investigated the effects of bepridil on electrophysiological properties and spiral-wave (SW) reentry in a 2-dimensional ventricular muscle layer of iso...