Antisense Oligonucleotide Inhibition of MicroRNA-494 Halts Atherosclerotic Plaque Progression and Promotes Plaque Stabilization

• Үндсэн зохиолчид: Eva van Ingen (Зохиогч), Amanda C. Foks (Зохиогч), Mara J. Kröner (Зохиогч), Johan Kuiper (Зохиогч), Paul H.A. Quax (Зохиогч), Ilze Bot (Зохиогч), Anne Yaël Nossent (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2019-12-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

We have previously shown that third-generation antisense (3GA) inhibition of 14q32 microRNA (miRNA)-494 reduced early development of atherosclerosis. However, patients at risk of atherosclerotic complications generally present with advanced and unstable lesions. Here, we administered 3GAs against 14...