Protein Kinase C Activation by Helicobacter pylori in Human Gastric Epithelial Cells Limits Interleukin-8 Production Through Suppression of Extracellular Signal-Regulated Kinase

• Main Authors: Yoshihisa Nozawa (Author), Katsushi Nishihara (Author), Yushiro Akizawa (Author), Naoki Orimoto (Author), Motoko Nakano (Author), Tatsuya Uji (Author), Hirofusa Ajioka (Author), Atsuhiro Kanda (Author), Naosuke Matsuura (Author), Mamoru Kiniwa (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Helicobacter pylori (H. pylori) infection of gastric epithelial cells has been shown to induce interleukin (IL)-8 production, but the signal transduction mechanism leading to IL-8 production has not been clearly defined. Here, we investigate the role of protein kinase C (PKC) in the mechanism of ind...