Absolute bioavailability, dose proportionality, and tissue distribution of rotundic acid in rats based on validated LC-QqQ-MS/MS method

• Main Authors: Haihua Shang (Author), Xiaohan Dai (Author), Mi Li (Author), Yueyi Kai (Author), Zerong Liu (Author), Min Wang (Author), Quansheng Li (Author), Yuan Gu (Author), Changxiao Liu (Author), Duanyun Si (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rotundic acid (RA), an ursane-type pentacyclic triterpene acid isolated from the dried barks of Ilex rotunda Thunb. (Aquifoliaceae), possesses diverse bioactivities. To further study its pharmacokinetics, a simple and sensitive liquid chromatography with triple quadrupole mass spectrometry (LC-QqQ-M...