Xanthates As Useful Probes for Testing the Active Sites of Cytochromes P450 4A11 and 2E1

• मुख्य लेखकों: Tsveta Stoyanova (लेखक), Iglika Lessigiarska (लेखक), Momir Mikov (लेखक), Ilza Pajeva (लेखक), Stanislav Yanev (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2017-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Xanthates (alkyl or aryl derivatives of dithiocarbonic acid) have been shown to be selective mechanism-based inactivators of cytochromes P450 2B1/2B6 and 2E1 due to covalent binding of a reactive intermediate to apoprotein after double hydrogen abstraction at α-carbon atom, suggesting interaction of...