Celastrol Attenuates RANKL-Induced Osteoclastogenesis in vitro and Reduces Titanium Particle-Induced Osteolysis and Ovariectomy-Induced Bone Loss in vivo

• Váldodahkkit: Qiang Xu (Dahkki), Guiping Chen (Dahkki), Huaen Xu (Dahkki), Guoming Xia (Dahkki), Meisong Zhu (Dahkki), Haibo Zhan (Dahkki), Bin Zhang (Dahkki), Min Dai (Dahkki), Hongxian Fan (Dahkki), Xuqiang Liu (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Excessive bone resorption by osteoclasts contributes significantly to osteoclast-related diseases such as periprosthetic osteolysis and osteoporosis. Osteolysis in a titanium particle-induced calvarial model and bone loss in an ovariectomized mice model occurred similarly to those in humans; thus, t...