Celastrol Attenuates RANKL-Induced Osteoclastogenesis in vitro and Reduces Titanium Particle-Induced Osteolysis and Ovariectomy-Induced Bone Loss in vivo

• Main Authors: Qiang Xu (Author), Guiping Chen (Author), Huaen Xu (Author), Guoming Xia (Author), Meisong Zhu (Author), Haibo Zhan (Author), Bin Zhang (Author), Min Dai (Author), Hongxian Fan (Author), Xuqiang Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Excessive bone resorption by osteoclasts contributes significantly to osteoclast-related diseases such as periprosthetic osteolysis and osteoporosis. Osteolysis in a titanium particle-induced calvarial model and bone loss in an ovariectomized mice model occurred similarly to those in humans; thus, t...