Comparison of dose selection based on target engagement versus inhibition of receptor-ligand interaction for checkpoint inhibitors

Abstract Immune checkpoint inhibitors block the interaction between a receptor on one cell and its ligand on another cell, thus preventing the transduction of an immunosuppressive signal. While inhibition of the receptor-ligand interaction is key to the pharmacological activity of these drugs, it ca...

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Main Authors: Sarah A. Head (Author), Carter Johnson (Author), Saheli Sarkar (Author), Andrew Matteson (Author), Diana H. Marcantonio (Author), Fei Hua (Author), John M. Burke (Author), Joshua F. Apgar (Author), David Flowers (Author)
Format: Book
Published: Wiley, 2024-06-01T00:00:00Z.
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