Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm

• Main Authors: Iris I. Müller (Author), David B. Melville (Author), Vineeta Tanwar (Author), Witold M. Rybski (Author), Amrita Mukherjee (Author), M. Benjamin Shoemaker (Author), Wan-Der Wang (Author), John A. Schoenhard (Author), Dan M. Roden (Author), Dawood Darbar (Author), Ela W. Knapik (Author), Antonis K. Hatzopoulos (Author)
• Format: Book
• Published: The Company of Biologists, 2013-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Atrial fibrillation (AF) is the most common cardiac arrhythmia and carries a significant risk of stroke and heart failure. The molecular etiologies of AF are poorly understood, leaving patients with limited therapeutic options. AF has been recognized as an inherited disease in almost 30% of...