Duplication of SOX3 in an SRY-negative 46,XX male with prostatic utricle: case report and literature review

• Main Authors: Jiansheng Wei (Author), Changrong Liu (Author), Minyan Zhang (Author), Shen Liu (Author), Junjie Fu (Author), Peng Lin (Author)
• Format: Book
• Published: BMC, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background 46,XX male disorders of sex development are rare. Approximately 80% of cases of testicular tissue differentiation may be due to translocation of SRY to the X chromosome or an autosome. SRY-negative 46,XX males show overexpression of pro-testis genes, such as SOX9 and SOX3, or fai...