Maternal infection with Trypanosoma cruzi and congenital Chagas disease induce a trend to a type 1 polarization of infant immune responses to vaccines.

• Main Authors: Nicolas Dauby (Author), Cristina Alonso-Vega (Author), Eduardo Suarez (Author), Amilcar Flores (Author), Emmanuel Hermann (Author), Marisol Córdova (Author), Tatiana Tellez (Author), Faustino Torrico (Author), Carine Truyens (Author), Yves Carlier (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: We previously showed that newborns congenitally infected with Trypanosoma cruzi (M+B+) display a strong type 1 parasite-specific T cell immune response, whereas uninfected newborns from T. cruzi-infected mothers (M+B-) are prone to produce higher levels of proinflammatory cytokines than...