Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody

• Main Authors: Jeffrey S. Boyles (Author), Catherine B. Beidler (Author), Beth A. Strifler (Author), Daniel S. Girard (Author), Zhanna Druzina (Author), Jim D. Durbin (Author), Michelle L. Swearingen (Author), Linda N. Lee (Author), Kristine Kikly (Author), Sudhakar Chintharlapalli (Author), Derrick R. Witcher (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CXCR1 and CXCR2 signaling play a critical role in neutrophil migration, angiogenesis, and tumorigenesis and are therefore an attractive signaling axis to target in a variety of indications. In human, a total of seven chemokines signal through these receptors and comprise the ELR+CXC chemokine family...