Exercise, programmed cell death and exhaustion of cardiomyocyte proliferation in aging zebrafish

• Main Authors: Lindsay B. Murphy (Author), Adrian Santos-Ledo (Author), Tamilvendhan Dhanaseelan (Author), Lorraine Eley (Author), David Burns (Author), Deborah J. Henderson (Author), Bill Chaudhry (Author)
• Format: Book
• Published: The Company of Biologists, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Exercise may ameliorate the eventual heart failure inherent in human aging. In this study, we use zebrafish to understand how aging and exercise affect cardiomyocyte turnover and myocardial remodelling. We show that cardiomyocyte proliferation remains constant throughout life but that onset of fibro...