Quantitation of certolizumab pegol by validated liquid chromatography methods

• Main Authors: Clóvis Dervil Appratto Cardoso Júnior (Author), Bruna Xavier (Author), Rafaela Ferreira Perobelli Dumoncel (Author), Francielle Santos da Silva (Author), Sérgio Luiz Dalmora (Author)
• Format: Book
• Published: Universidade de São Paulo, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Certolizumab pegol (CZP) is a Fab' fragment of the humanized antibody with anti-TNF-α activity that is indicated as therapy for Crohn's disease and rheumatoid arthritis. Using a BioSep-SEC-S3000 column (300 x 4.6 mm i.d., 5 µm particle size), a size exclusion liquid chromatography...