Optimization of small molecule degraders and antagonists for targeting estrogen receptor based on breast cancer: current status and future

• Main Authors: Jiaqi Yao (Author), Yiran Tao (Author), Zelin Hu (Author), Junjie Li (Author), Ziyi Xue (Author), Ya Zhang (Author), Yi Lei (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The estrogen receptor (ER) is a classical receptor protein that plays a crucial role in mediating multiple signaling pathways in various target organs. It has been shown that ER-targeting therapies inhibit breast cancer cell proliferation, enhance neuronal protection, and promote osteoclast formatio...