Transgenic mice as an alternative to monkeys for neurovirulence testing of live oral poliovirus vaccine: validation by a WHO collaborative study

• Main Authors: Dragunsky Eugenia (Author), Nomura Tatsuji (Author), Karpinski Kazimir (Author), Furesz John (Author), Wood David J. (Author), Pervikov Yuri (Author), Abe Shinobu (Author), Kurata Takeshi (Author), Vanloocke Olivier (Author), Karganova Galina (Author), Taffs Rolf (Author), Heath Alan (Author), Ivshina Anna (Author), Levenbook Inessa (Author)
• Format: Book
• Published: The World Health Organization, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

OBJECTIVE: Extensive WHO collaborative studies were performed to evaluate the suitability of transgenic mice susceptible to poliovirus (TgPVR mice, strain 21, bred and provided by the Central Institute for Experimental Animals, Japan) as an alternative to monkeys in the neurovirulence test (NVT) of...