Do the mutations of <it>C1GALT1C1 </it>gene play important roles in the genetic susceptibility to Chinese IgA nephropathy?

• Main Authors: LV Ji-Cheng (Author), Zhang Hong (Author), Nie Guang-Jun (Author), Li Gui-Sen (Author), Shen Yan (Author), Wang Hai-Yan (Author)
• Format: Book
• Published: BMC, 2009-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The deficiency of <it>β</it>1,3 galactose in hinge region of IgA1 molecule played a pivotal role in pathogenesis of IgA nephropathy (IgAN). Cosmc, encoded by <it>C1GALT1C1 </it>gene, was indispensable to <i...