A size-shrinkable matrix metallopeptidase-2-sensitive delivery nanosystem improves the penetration of human programmed death-ligand 1 siRNA into lung-tumor spheroids

• Main Authors: Jiaolin Wen (Author), Neng Qiu (Author), Zejiang Zhu (Author), Peng Bai (Author), Mengshi Hu (Author), Wenyan Qi (Author), Yan Liu (Author), Ailin Wei (Author), Lijuan Chen (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Given the maturation of small-interfering RNA (siRNA) techniques with nanotechnology, and because overexpression of human programmed death-ligand 1 (PD-L1) is crucial for T cell inactivation and immunosuppression of the tumor microenvironment, application of siRNA-PD-L1 has demonstrated positive pro...