Characterization of Compound-Specific, Concentration-Independent Biophysical Properties of Sodium Channel Inhibitor Mechanism of Action Using Automated Patch-Clamp Electrophysiology

We have developed an automated patch-clamp protocol that allows high information content screening of sodium channel inhibitor compounds. We have observed that individual compounds had their specific signature patterns of inhibition, which were manifested irrespective of the concentration. Our aim i...

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Main Authors: Krisztina Pesti (Author), Mátyás C. Földi (Author), Katalin Zboray (Author), Adam V. Toth (Author), Peter Lukacs (Author), Arpad Mike (Author)
Format: Book
Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
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