Blood Pressure-Lowering Effect of Wine Lees Phenolic Compounds Is Mediated by Endothelial-Derived Factors: Role of Sirtuin 1

• Main Authors: Raúl López-Fer (Author), Jorge R. Soliz-Rueda (Author), Javier Ávila-Román (Author), Anna Arola-Arnal (Author), Manuel Suárez (Author), Begoña Muguerza (Author), Francisca Isabel Bravo (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The antihypertensive effect of wine lees powder (WLPW) from a Cabernet grape variety was related to its high content in flavanols and anthocyanins compounds. This study investigates the involvement of endothelial-derived factors and SIRT1 in its bioactivity. Spontaneously hypertensive rats (SHR) wer...