Nitric Oxide Is a Mediator of Antiproliferative Effects Induced by Proinflammatory Cytokines on Pancreatic Beta Cells

• Autori principali: Laura Quintana-Lopez (Autore), Manuel Blandino-Rosano (Autore), Gonzalo Perez-Arana (Autore), Alberto Cebada-Aleu (Autore), Alfonso Lechuga-Sancho (Autore), Manuel Aguilar-Diosdado (Autore), Carmen Segundo (Autore)
• Natura: Libro
• Pubblicazione: Hindawi Limited, 2013-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Nitric oxide (NO) is involved in several biological processes. In type 1 diabetes mellitus (T1DM), proinflammatory cytokines activate an inducible isoform of NOS (iNOS) in β cells, thus increasing NO levels and inducing apoptosis. The aim of the current study is to determine the role of NO (1) in th...