Live attenuated influenza vaccine viral vector induces functional cytotoxic T-cell immune response against foreign CD8+ T-cell epitopes inserted into NA and NS1 genes using the 2A self-cleavage site

• 主要な著者: Tatiana Kotomina (著者), Daniil Korenkov (著者), Victoria Matyushenko (著者), Polina Prokopenko (著者), Larisa Rudenko (著者), Irina Isakova-Sivak (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2018-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The development of viral vector vaccines against various pathogens for which conventional vaccination approaches are not applicable has been a priority for a number of years. One promising approach is the insertion of immunodominant conservative cytotoxic T-cell (CTL) epitopes into the genome of a v...