Live attenuated influenza vaccine viral vector induces functional cytotoxic T-cell immune response against foreign CD8+ T-cell epitopes inserted into NA and NS1 genes using the 2A self-cleavage site

• Main Authors: Tatiana Kotomina (Author), Daniil Korenkov (Author), Victoria Matyushenko (Author), Polina Prokopenko (Author), Larisa Rudenko (Author), Irina Isakova-Sivak (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of viral vector vaccines against various pathogens for which conventional vaccination approaches are not applicable has been a priority for a number of years. One promising approach is the insertion of immunodominant conservative cytotoxic T-cell (CTL) epitopes into the genome of a v...