Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice

• Main Authors: Kana IKEGAMI (Author), Teppei GOTO (Author), Sho NAKAMURA (Author), Youki WATANABE (Author), Arisa SUGIMOTO (Author), Sutisa MAJARUNE (Author), Kei HORIHATA (Author), Mayuko NAGAE (Author), Junko TOMIKAWA (Author), Takuya IMAMURA (Author), Makoto SANBO (Author), Masumi HIRABAYASHI (Author), Naoko INOUE (Author), Kei-ichiro MAEDA (Author), Hiroko TSUKAMURA (Author), Yoshihisa UENOYAMA (Author)
• Format: Book
• Published: The Society for Reproduction and Development, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study aimed to evaluate whether novel conditional kisspeptin neuron-specific Kiss1 knockout (KO) mice utilizing the Cre-loxP system could recapitulate the infertility of global Kiss1 KO models, thereby providing further evidence for the fundamental role of hypothalamic kisspeptin neurons...