Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice

• Главные авторы: Kana IKEGAMI (Автор), Teppei GOTO (Автор), Sho NAKAMURA (Автор), Youki WATANABE (Автор), Arisa SUGIMOTO (Автор), Sutisa MAJARUNE (Автор), Kei HORIHATA (Автор), Mayuko NAGAE (Автор), Junko TOMIKAWA (Автор), Takuya IMAMURA (Автор), Makoto SANBO (Автор), Masumi HIRABAYASHI (Автор), Naoko INOUE (Автор), Kei-ichiro MAEDA (Автор), Hiroko TSUKAMURA (Автор), Yoshihisa UENOYAMA (Автор)
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• Опубликовано: The Society for Reproduction and Development, 2020-04-01T00:00:00Z.
• Предметы: article
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The present study aimed to evaluate whether novel conditional kisspeptin neuron-specific Kiss1 knockout (KO) mice utilizing the Cre-loxP system could recapitulate the infertility of global Kiss1 KO models, thereby providing further evidence for the fundamental role of hypothalamic kisspeptin neurons...