CD4+ T Cells Modified by the Endoribonuclease MazF Are Safe and Can Persist in SHIV-infected Rhesus Macaques

CD4+ T Cells Modified by the Endoribonuclease MazF Are Safe and Can Persist in SHIV-infected Rhesus Macaques

MazF, an endoribonuclease encoded by Escherichia coli, specifically cleaves the ACA (adenine-cytosine-adenine) sequence of single-stranded RNAs. Conditional expression of MazF under the control of the HIV-1 LTR promoter rendered CD4+ T cells resistant to HIV-1 replication without affecting cell grow...

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Main Authors: Naoki Saito (Author), Hideto Chono (Author), Hiroaki Shibata (Author), Naohide Ageyama (Author), Yasuhiro Yasutomi (Author), Junichi Mineno (Author)
Format: Book
Published: Elsevier, 2014-01-01T00:00:00Z.
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