A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers

• Main Authors: Romualdo Troisi (Author), Claudia Riccardi (Author), Kévan Pérez de Carvasal (Author), Michael Smietana (Author), François Morvan (Author), Pompea Del Vecchio (Author), Daniela Montesarchio (Author), Filomena Sica (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite their unquestionable properties, oligonucleotide aptamers display some drawbacks that continue to hinder their applications. Several strategies have been undertaken to overcome these weaknesses, using thrombin binding aptamers as proof-of-concept. In particular, the functionalization of a th...