Design, Molecular Docking, Synthesis, Anticancer and Anti-Hyperglycemic Assessments of Thiazolidine-2,4-diones Bearing Sulfonylthiourea Moieties as Potent VEGFR-2 Inhibitors and PPARγ Agonists

• Auteurs principaux: Mohamed A. Abdelgawad (Auteur), Khaled El-Adl (Auteur), Sanadelaslam S. A. El-Hddad (Auteur), Mostafa M. Elhady (Auteur), Nashwa M. Saleh (Auteur), Mohamed M. Khalifa (Auteur), Fathalla Khedr (Auteur), Mohamed Alswah (Auteur), AbdElAziz A. Nayl (Auteur), Mohammed M. Ghoneim (Auteur), Nour E. A. Abd El-Sattar (Auteur)
• Format: Livre
• Publié: MDPI AG, 2022-02-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Newly designed thiazolidine-2,4-diones <b>3</b>-<b>7a</b>-<b>c</b> were synthesized, and their anticancer activities were screened against three cancer lines. They showed potent activities against HepG2 compared to the other HCT116 and MCF-7 tumor cell lines. Comp...