Estimation of the octanol-water distribution coefficient of basic compounds by a cationic microemulsion electrokinetic chromatography system

• Main Authors: Alejandro Fernández-Pumarega (Author), Belén Martín-Sanz (Author), Susana Amézqueta (Author), Elisabet Fuguet (Author), Martí Rosés (Author)
• 格式: 圖書
• 出版: International Association of Physical Chemists (IAPC), 2020-03-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

The octanol-water partition coefficient (Po/w), or the octanol-water distribution coefficient (Do/w) for ionized compounds, is a key parameter in the drug development process. In a previous work, this parameter was estimated through the retention factor measurements in a sodium dodecyl sulfate (SDS)...