Inclusion complexes and self-assembled cyclodextrin aggregates for increasing the solubility of benzimidazoles

• Главные авторы: Leticia Norma Carpentieri Rodrigues (Автор), Anna Carollina Moraes Tavares (Автор), Beatriz Tavares Ferreira (Автор), Adriana Karla Cardoso Amorim Reis (Автор), Luciana Morita Katiki (Автор)
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• Опубликовано: Universidade de São Paulo, 2019-11-01T00:00:00Z.
• Предметы: article
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Albendazole and fenbendazole are imidazole derivatives that exhibit broad spectrum activity against parasites, but the low solubility of these drugs considerably reduces their effectiveness. Complexation of albendazole and fenbendazole with cyclodextrins (β-cyclodextrin and hydroxypropyl-β-cyclodext...