Inclusion complexes and self-assembled cyclodextrin aggregates for increasing the solubility of benzimidazoles

• Auteurs principaux: Leticia Norma Carpentieri Rodrigues (Auteur), Anna Carollina Moraes Tavares (Auteur), Beatriz Tavares Ferreira (Auteur), Adriana Karla Cardoso Amorim Reis (Auteur), Luciana Morita Katiki (Auteur)
• Format: Livre
• Publié: Universidade de São Paulo, 2019-11-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Albendazole and fenbendazole are imidazole derivatives that exhibit broad spectrum activity against parasites, but the low solubility of these drugs considerably reduces their effectiveness. Complexation of albendazole and fenbendazole with cyclodextrins (β-cyclodextrin and hydroxypropyl-β-cyclodext...