CoenzymeQ10 and Ischemic Preconditioning Potentially Prevent Tourniquet-Induced Ischemia/Reperfusion in Knee Arthroplasty, but Combined Pretreatment Possibly Neutralizes Their Beneficial Effects

• Main Authors: Prangmalee Leurcharusmee (Author), Passakorn Sawaddiruk (Author), Yodying Punjasawadwong (Author), Nantawit Sugundhavesa (Author), Kasisin Klunklin (Author), Siam Tongprasert (Author), Patraporn Sitilertpisan (Author), Thidarat Jaiwongkam (Author), Nattayaporn Apaijai (Author), Nipon Chattipakorn (Author), Siriporn C. Chattipakorn (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tourniquet (TQ) use during total knee arthroplasty (TKA) induces ischemia/reperfusion (I/R) injury, resulting in mitochondrial dysfunction. This study aims to determine the effects of coenzyme Q10 (CoQ10) and ischemic preconditioning (IPC), either alone or in combination, on I/R-induced mitochondria...