Structure-Activity Relationship of Pyrrolidine Pentamine Derivatives as Inhibitors of the Aminoglycoside 6'-<i>N</i>-Acetyltransferase Type Ib

Structure-Activity Relationship of Pyrrolidine Pentamine Derivatives as Inhibitors of the Aminoglycoside 6'-<i>N</i>-Acetyltransferase Type Ib

Resistance to amikacin and other major aminoglycosides is commonly due to enzymatic acetylation by the aminoglycoside 6'-<i>N</i>-acetyltransferase type I enzyme, of which type Ib [AAC(6')-Ib] is the most widespread among Gram-negative pathogens. Finding enzymatic inhibitors co...

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Main Authors: Jan Sklenicka (Author), Tung Tran (Author), Maria S. Ramirez (Author), Haley M. Donow (Author), Angel J. Magaña (Author), Travis LaVoi (Author), Yasir Mamun (Author), Verónica Jimenez (Author), Prem Chapagain (Author), Radleigh Santos (Author), Clemencia Pinilla (Author), Marc A. Giulianotti (Author), Marcelo E. Tolmasky (Author)
Format: Book
Published: MDPI AG, 2024-07-01T00:00:00Z.
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