Pyr1-Mediated Pharmacological Inhibition of LIM Kinase Restores Synaptic Plasticity and Normal Behavior in a Mouse Model of Schizophrenia

• Main Authors: Sylvie Gory-Fauré (Author), Rebecca Powell (Author), Julie Jonckheere (Author), Fabien Lanté (Author), Eric Denarier (Author), Leticia Peris (Author), Chi Hung Nguyen (Author), Alain Buisson (Author), Laurence Lafanechère (Author), Annie Andrieux (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The search for effective treatments for neuropsychiatric disorders is ongoing, with progress being made as brain structure and neuronal function become clearer. The central roles played by microtubules (MT) and actin in synaptic transmission and plasticity suggest that the cytoskeleton and its modul...