Thrombin Promotes Matrix Metalloproteinase-13 Expression through the PKCδ/c-Src/EGFR/PI3K/Akt/AP-1 Signaling Pathway in Human Chondrocytes

• Glavni autori: Chun-Yin Huang (Autor), Hsiu-Jung Lin (Autor), Hsin-Shui Chen (Autor), Shi-Yann Cheng (Autor), Horng-Chaung Hsu (Autor), Chih-Hsin Tang (Autor)
• Format: Knjiga
• Izdano: Hindawi Limited, 2013-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Thrombin is a key mediator of fibrin deposition, angiogenesis, and proinflammatory processes. Abnormalities in these processes are primary features of rheumatoid arthritis and osteoarthritis. Matrix metalloproteinase-13 (MMP-13) may contribute to the breakdown of articular cartilage during arthritis...