Thrombin Promotes Matrix Metalloproteinase-13 Expression through the PKCδ/c-Src/EGFR/PI3K/Akt/AP-1 Signaling Pathway in Human Chondrocytes

• Main Authors: Chun-Yin Huang (Author), Hsiu-Jung Lin (Author), Hsin-Shui Chen (Author), Shi-Yann Cheng (Author), Horng-Chaung Hsu (Author), Chih-Hsin Tang (Author)
• 格式: 图书
• 出版: Hindawi Limited, 2013-01-01T00:00:00Z.
• 主题: article
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Thrombin is a key mediator of fibrin deposition, angiogenesis, and proinflammatory processes. Abnormalities in these processes are primary features of rheumatoid arthritis and osteoarthritis. Matrix metalloproteinase-13 (MMP-13) may contribute to the breakdown of articular cartilage during arthritis...