A Microphysiological Cell-Culturing System for Pharmacokinetic Drug Exposure and High-Resolution Imaging of Arrays of 3D Microtissues

• Main Authors: Christian Lohasz (Author), Jacqueline Loretan (Author), Dario Sterker (Author), Ekkehard Görlach (Author), Kasper Renggli (Author), Paul Argast (Author), Olivier Frey (Author), Marion Wiesmann (Author), Markus Wartmann (Author), Martin Rausch (Author), Andreas Hierlemann (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Understanding the pharmacokinetic/pharmacodynamic (PK/PD)-relationship of a drug candidate is key to determine effective, yet safe treatment regimens for patients. However, current testing strategies are inefficient in characterizing in vivo responses to fluctuating drug concentrations during multi-...