A Novel ALDH2 Activator AD-9308 Improves Diastolic and Systolic Myocardial Functions in Streptozotocin-Induced Diabetic Mice

• Main Authors: Hsiao-Lin Lee (Author), Siow-Wey Hee (Author), Chin-Feng Hsuan (Author), Wenjin Yang (Author), Jing-Yong Huang (Author), Ya-Ling Lin (Author), Chih-Neng Hsu (Author), Juey-Jen Hwang (Author), Shiau-Mei Chen (Author), Zhi-Zhong Ding (Author), Tung-Yuan Lee (Author), Yu-Chiao Lin (Author), Feng-Chiao Tsai (Author), Wei-Lun Su (Author), Li-Yun Chueh (Author), Meng-Lun Hsieh (Author), Che-Hong Chen (Author), Daria Mochly-Rosen (Author), Yi-Cheng Chang (Author), Lee-Ming Chuang (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diabetes mellitus has reached epidemic proportion worldwide. One of the diabetic complications is cardiomyopathy, characterized by early left ventricular (LV) diastolic dysfunction, followed by development of systolic dysfunction and ventricular dilation at a late stage. The pathogenesis is multifac...