Estrogen-sensitive activation of SGK1 induces M2 macrophages with anti-inflammatory properties and a Th2 response at the maternal-fetal interface

• Main Authors: Yiyun Lou (Author), Zhujing Fu (Author), Ye Tian (Author), Minhao Hu (Author), Qijing Wang (Author), Yuanyuan Zhou (Author), Ning Wang (Author), Qin Zhang (Author), Fan Jin (Author)
• Format: Book
• Published: BMC, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Decidual macrophages participate in immune regulation at the maternal-fetal interface. Abnormal M1/M2 polarization of decidual macrophages might predispose immune maladaptation in recurrent pregnancy loss (RPL). However, the mechanism of decidual macrophage polarization is unclea...