High-throughput modular click chemistry synthesis of catechol derivatives as covalent inhibitors of SARS-CoV-2 3CLpro

The 3C-like protease (3CLpro) is a crucial target in anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) drug design. Herein, we performed high-throughput synthesis of catechol derivatives from the bioactive catechol-terminal alkyne scaffold A4, by using modular click chemistry. Subseq...

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主要な著者: Feng Wang (著者), Tiancheng Ma (著者), Donglan Liu (著者), Yixin Cen (著者), Shidong Deng (著者), Lu Zhang (著者), Guoqiang Lin (著者), Dingding Gao (著者), Jincun Zhao (著者), Jiajia Dong (著者), Ping Tian (著者)
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出版事項: Compuscript Ltd, 2024-09-01T00:00:00Z.
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