Elucidating a Complicated Enantioselective Metabolic Profile: A Study From Rats to Humans Using Optically Pure Doxazosin

Elucidating a Complicated Enantioselective Metabolic Profile: A Study From Rats to Humans Using Optically Pure Doxazosin

Doxazosin (DOX) is prescribed as a racemic drug for the clinical treatment of benign prostatic hyperplasia and hypertension. Recent studies found that the two enantiomers of DOX exhibit differences in blood concentration and pharmacological effects. However, the stereoselective metabolic characteris...

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Main Authors: Dezhi Kong (Author), Yuan Tian (Author), Kunfeng Duan (Author), Wenyan Guo (Author), Qingning Zhang (Author), Panpan Zhang (Author), Zuxiao Yang (Author), Xia Qin (Author), Leiming Ren (Author), Wei Zhang (Author)
Format: Book
Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
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