Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders

• Main Authors: Federico Tessadori (Author), Helen I. Roessler (Author), Sanne M. C. Savelberg (Author), Sonja Chocron (Author), Sarah M. Kamel (Author), Karen J. Duran (Author), Mieke M. van Haelst (Author), Gijs van Haaften (Author), Jeroen Bakkers (Author)
• Format: Book
• Published: The Company of Biologists, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The zebrafish (Danio rerio) has become a popular vertebrate model organism to study organ formation and function due to its optical clarity and rapid embryonic development. The use of genetically modified zebrafish has also allowed identification of new putative therapeutic drugs. So far, most studi...