Development of mouse models of angiosarcoma driven by p53

• Main Authors: Donald M. Salter (Author), Meredyth Griffin (Author), Morwenna Muir (Author), Katy Teo (Author), Jayne Culley (Author), James R. Smith (Author), Laura Gomez-Cuadrado (Author), Kylie Matchett (Author), Andrew H. Sims (Author), Larry Hayward (Author), Neil C. Henderson (Author), Valerie G. Brunton (Author)
• Format: Book
• Published: The Company of Biologists, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Angiosarcomas are a rare group of tumours which have poor prognosis and limited treatment options. The development of new therapies has been hampered by a lack of good preclinical models. Here, we describe the development of an autochthonous mouse model of angiosarcoma driven by loss of p53 in VE-ca...