First-in-human study of D6-[18F]FP-(+)-DTBZ, a novel VMAT2 tracer: whole-body biodistribution and brain PET comparison with [18F]FP-(+)-DTBZ (AV-133)

• Main Authors: Ruiyue Zhao (Author), Jinhua Chen (Author), Ting Ye (Author), Jianmin Chu (Author), Jingwen Li (Author), Yan Zhang (Author), Siran Xu (Author), Shaoyu Liu (Author), Ling Chen (Author), Karl Ploessl (Author), David Alexoff (Author), Hank F. Kung (Author), Lin Zhu (Author), Xinlu Wang (Author)
• Format: Book
• Published: SpringerOpen, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background In the central nervous system, type 2 vesicular monoamine transporters (VMAT2) are responsible for the reuptake of monoamines from synaptic junction back to pre-synaptic terminal vesicles. These transporters are functionally crucial as they reflect the integrity of monoamine neur...