Preformulation of a liquid dosage formulation of captopril for pediatric use: drug-excipient compatibility and stability studies

• Main Authors: Janaina da Silva Goes (Author), Fátima Duarte Freire (Author), Túlio Flávio Accioly de Lima e Moura (Author), Cícero Flávio Soares Aragão (Author), Fernanda Nervo Raffin (Author)
• Format: Book
• Published: Universidade de São Paulo, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Currently, medications used in children are typically modified from pharmaceutical dosage forms designed for adults. Captopril is widely adapted to liquid formulations for use in hospitals. Its stability in the aqueous medium is reduced since it undergoes oxidation producing captopril disulfide (its...