Effect of a Hygiene Protocol on Denture-Related Stomatitis Remission, Local Inflammatory Factors, and Hemodynamic Responses by Arterial Pressure

• Main Authors: Adriana Barbosa Ribeiro (Author), Aline Barbosa Ribeiro (Author), Camila Borba de Araújo (Author), Caroline Vieira Fortes (Author), Lorena Mosconi Clemente (Author), Helena de Freitas Oliveira Paranhos (Author), Evandro Watanabe (Author), Helio Cesar Salgado (Author), Cláudia Helena Silva-Lovato (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Denture-related stomatitis (DRS) is frequent oral inflammation in complete denture wearers. This study evaluated the effect of a hygiene protocol on DRS remission, local inflammatory factors, and hemodynamic responses. Thirty-three individuals were enrolled in the study. The outcomes were measured before and after 10 days of a hygiene protocol treatment consisting of brushing the palate with a soft brush and water and denture brushing with a denture-specific brush and mild soap, as well as immersion of the denture for 20 min in a 0.25% sodium hypochlorite solution. Data were analyzed by paired Wilcoxon for biofilm removal and CFU count of microorganisms. The paired T test was used to assess salivary MUC 1, cytokines, and arterial pressure (<i>p</i> < 0.05). A significant difference was found in the DRS degree (<i>p</i> < 0.001), biofilm (<i>p</i> < 0.001), microbial load of <i>Candida</i> spp. (<i>p</i> < 0.001), Gram-negative (<i>p</i> < 0.004), <i>Staphylococcus</i> spp. (<i>p</i> < 0.001), and <i>S. mutans</i> (<i>p</i> < 0.001) of the denture, and <i>S. mutans</i> (<i>p</i> < 0.001) of the palate after use of the protocol. The salivary flow (<i>p</i> = 0.2) and pH (<i>p</i> = 0.97) did not change; there was an increase of MUC 1 (<i>p</i> = 0.049) and a decrease in IL-6 (<i>p</i> = 0.038), IL-2 (<i>p</i> = 0.04), IL-10 (<i>p</i> = 0.041), and IFNγ (<i>p</i> = 0.04). There was also a decrease in systolic (<i>p</i> = 0.012) and mean arterial pressure (<i>p</i> = 0.02). The current hygiene protocol reduced the inflammation degree of DRS and promoted an improvement of local inflammatory factors and a reduction in the systolic arterial pressure of the patients.

Item Description

10.3390/antibiotics11101320
2079-6382