Trends in H<sub>2</sub>S-Donors Chemistry and Their Effects in Cardiovascular Diseases
Hydrogen sulfide (H<sub>2</sub>S) is an endogenous gasotransmitter recently emerged as an important regulatory mediator of numerous human cell functions in health and in disease. In fact, much evidence has suggested that hydrogen sulfide plays a significant role in many physio-pathologic...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2021-03-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Hydrogen sulfide (H<sub>2</sub>S) is an endogenous gasotransmitter recently emerged as an important regulatory mediator of numerous human cell functions in health and in disease. In fact, much evidence has suggested that hydrogen sulfide plays a significant role in many physio-pathological processes, such as inflammation, oxidation, neurophysiology, ion channels regulation, cardiovascular protection, endocrine regulation, and tumor progression. Considering the plethora of physiological effects of this gasotransmitter, the protective role of H<sub>2</sub>S donors in different disease models has been extensively studied. Based on the growing interest in H<sub>2</sub>S-releasing compounds and their importance as tools for biological and pharmacological studies, this review is an exploration of currently available H<sub>2</sub>S donors, classifying them by the H<sub>2</sub>S-releasing-triggered mechanism and highlighting those potentially useful as promising drugs in the treatment of cardiovascular diseases. |
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| Item Description: | 10.3390/antiox10030429 2076-3921 |