Impact of Tigecycline Versus Other Antibiotics on the Fecal Metabolome and on Colonization Resistance to Clostridium difficile in Mice

• Autors principals: Robin L.P. Jump (Autor), David Kraft (Autor), Kelly Hurless (Autor), Alex Polinkovsky (Autor), Curtis J. Donskey (Autor)
• Format: Llibre
• Publicat: Case Western Reserve University, 2017-01-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Background: The glycylcycline antibiotic tigecycline may have a relatively low propensity to promote Clostridium difficile infection in part because it causes less disruption of the indigenous intestinal microbiota than other broad-spectrum antibiotics.  We used a mouse model to compare the compare...