Neutrophil Extracellular Traps are Involved in the Innate Immune Response to Infection with Leptospira.

• Main Authors: Emilia Scharrig (Author), Agostina Carestia (Author), María F Ferrer (Author), Maia Cédola (Author), Gabriela Pretre (Author), Ricardo Drut (Author), Mathieu Picardeau (Author), Mirta Schattner (Author), Ricardo M Gómez (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NETosis is a process by which neutrophils extrude their DNA together with bactericidal proteins that trap and/or kill pathogens. In the present study, we evaluated the ability of Leptospira spp. to induce NETosis using human ex vivo and murine in vivo models. Microscopy and fluorometric studies show...